Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway

نویسندگان

  • Carlos Perez-Plasencia
  • Alfonso Duenas-Gonzalez
  • Brenda Alatorre-Tavera
چکیده

The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis of the deregulation of wnt/beta-catenin signaling pathway as a "second hit" required to develop cervical cancer.

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عنوان ژورنال:
  • International Archives of Medicine

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2008